http://dspace.bsu.edu.ru/handle/123456789/47936| Title: | The tissue distribution of SARS-CoV-2 in transgenic mice with inducible ubiquitous expression of hACE2 |
| Authors: | Dolskiy, A. A. Gudymo, A. S. Taranov, O. S. Soldatov, V. O. Deykin, A. V. |
| Keywords: | medicine pharmacology antiviral agents COVID-19 SARS-CoV-2 intranasal infection transgenic mice hACE2 switch-on mice ACE2 Cre recombinase |
| Issue Date: | 2022 |
| Citation: | The tissue distribution of SARS-CoV-2 in transgenic mice with inducible ubiquitous expression of hACE2 / A.A. Dolskiy [et al.] // Frontiers in Molecular Biosciences. - 2022. - Vol.8.-Art. 821506. - Doi: doi: 10.3389/fmolb.2021.821506.- URL: https://www.frontiersin.org/articles/10.3389/fmolb.2021.821506/full |
| Abstract: | The novel coronavirus disease COVID-19 has become one of the most socially significant infections. One of the main models for COVID-19 pathogenesis study and anti-COVID-19 drug development is laboratory animals sensitive to the virus. Herein, we report SARSCoV- 2 infection in novel transgenic mice conditionally expressing human ACE2 (hACE2), with a focus on viral distribution after intranasal inoculation. Transgenic mice carrying hACE2 under the floxed STOP cassette [(hACE2-LoxP(STOP)] were mated with two types of Cre-ERT2 strains (UBC-Cre and Rosa-Cre) |
| URI: | http://dspace.bsu.edu.ru/handle/123456789/47936 |
| Appears in Collections: | Статьи из периодических изданий и сборников (на иностранных языках) = Articles from periodicals and collections (in foreign languages) |
| File | Description | Size | Format | |
|---|---|---|---|---|
| Soldatov_The Tissue.pdf | 2.38 MB | Adobe PDF | View/Open |
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