| DC Field | Value | Language |
|---|
| dc.contributor.author | Dolskiy, A. A. | - |
| dc.contributor.author | Gudymo, A. S. | - |
| dc.contributor.author | Taranov, O. S. | - |
| dc.contributor.author | Soldatov, V. O. | - |
| dc.contributor.author | Deykin, A. V. | - |
| dc.date.accessioned | 2022-10-17T14:12:09Z | - |
| dc.date.available | 2022-10-17T14:12:09Z | - |
| dc.date.issued | 2022 | - |
| dc.identifier.citation | The tissue distribution of SARS-CoV-2 in transgenic mice with inducible ubiquitous expression of hACE2 / A.A. Dolskiy [et al.] // Frontiers in Molecular Biosciences. - 2022. - Vol.8.-Art. 821506. - Doi: doi: 10.3389/fmolb.2021.821506.- URL: https://www.frontiersin.org/articles/10.3389/fmolb.2021.821506/full | ru |
| dc.identifier.uri | http://dspace.bsu.edu.ru/handle/123456789/47936 | - |
| dc.description.abstract | The novel coronavirus disease COVID-19 has become one of the most socially significant infections. One of the main models for COVID-19 pathogenesis study and anti-COVID-19 drug development is laboratory animals sensitive to the virus. Herein, we report SARSCoV- 2 infection in novel transgenic mice conditionally expressing human ACE2 (hACE2), with a focus on viral distribution after intranasal inoculation. Transgenic mice carrying hACE2 under the floxed STOP cassette [(hACE2-LoxP(STOP)] were mated with two types of Cre-ERT2 strains (UBC-Cre and Rosa-Cre) | ru |
| dc.language.iso | en | ru |
| dc.subject | medicine | ru |
| dc.subject | pharmacology | ru |
| dc.subject | antiviral agents | ru |
| dc.subject | COVID-19 | ru |
| dc.subject | SARS-CoV-2 | ru |
| dc.subject | intranasal infection | ru |
| dc.subject | transgenic mice | ru |
| dc.subject | hACE2 switch-on mice | ru |
| dc.subject | ACE2 | ru |
| dc.subject | Cre recombinase | ru |
| dc.title | The tissue distribution of SARS-CoV-2 in transgenic mice with inducible ubiquitous expression of hACE2 | ru |
| dc.type | Article | ru |
| Appears in Collections: | Статьи из периодических изданий и сборников (на иностранных языках) = Articles from periodicals and collections (in foreign languages)
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