http://dspace.bsu.edu.ru/handle/123456789/61085| Title: | New hybrid molecules based on sulfur-containing nicotinonitriles: synthesis, analgesic activity in acetic acid-induced writhing test, and molecular docking studies |
| Authors: | Krivokolysko, S. G. Dotsenko, V. V. Bibik, E. Yu. Samokish, A. A. Venidiktova, Y. S. |
| Keywords: | chemistry organic chemistry nicotinonitriles 1,4-dihydropyridines 1,4,5,6-tetrahydropyridines analgesics molecular docking |
| Issue Date: | 2022 |
| Citation: | New hybrid molecules based on sulfur-containing nicotinonitriles: synthesis, analgesic activity in acetic acid-induced writhing test, and molecular docking studies / S.G. Krivokolysko, V.V. Dotsenko, Bibik E.Yu. [et al.] // Russian Journal of Bioorganic Chemistry. - 2022. - Vol.48, №3.-P. 628-635. |
| Abstract: | New hybrid molecules bearing furyl and 1,4-dihydronicotinonitrile (or 1,4,5,6-tetrahydronicotinonitrile) fragments have been prepared. The analgesic activity was studied in vivo (rats) in acetic acidinduced writhing test. Some compounds showed activity exceeding that of the reference compound (metamizole) |
| URI: | http://dspace.bsu.edu.ru/handle/123456789/61085 |
| Appears in Collections: | Статьи из периодических изданий и сборников (на иностранных языках) = Articles from periodicals and collections (in foreign languages) |
| File | Description | Size | Format | |
|---|---|---|---|---|
| Dotsenko_New hybrid_22.pdf | 831.4 kB | Adobe PDF | View/Open |
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