http://dspace.bsu.edu.ru/handle/123456789/42472| Title: | The theory of interceptor-protector action of DNA binding drugs |
| Authors: | Evstigneev, M. P. Buchelnikov, A. S. Evstigneev, V. P. |
| Keywords: | biology physico-chemical biology interceptor action protector action DNA binding drugs molecular complexation |
| Issue Date: | 2019 |
| Citation: | Evstigneev, M.P. The theory of interceptor-protector action of DNA binding drugs / M.P. Evstigneev, A.S. Buchelnikov, V.P. Evstigneev // Progress in Biophysics and Molecular Biology. - 2019. - Vol.149.-P. 131-146. - Doi: https://doi.org/10.1016/j.pbiomolbio.2019.04.003. |
| Abstract: | The review discusses the theory of interceptor-protector action (the IPA theory) as the new selfconsistent biophysical theory establishing a quantitative interrelation between parameters measured in independent physico-chemical experiment and in vitro biological experiment for the class of DNA binding drugs. The elements of the theory provide complete algorithm of analysis, which may potentially be applied to any system of DNA targeting aromatic drugs. Such analytical schemes, apart from extension of current scientific knowledge, are important in the context of rational drug design for managing drug's response by changing the physico-chemical parameters of molecular complexation |
| URI: | http://dspace.bsu.edu.ru/handle/123456789/42472 |
| Appears in Collections: | Статьи из периодических изданий и сборников (на иностранных языках) = Articles from periodicals and collections (in foreign languages) |
| File | Description | Size | Format | |
|---|---|---|---|---|
| Evstigneev_The theory.pdf | 1.16 MB | Adobe PDF | View/Open |
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