Evaluation of the elastic properties and topography of leukocytes’ surface in patients with type 2 diabetes mellitus using atomic force microscope

Abstract

The aim of study was to examine some morphometrical parameters (height, diameter) of the leukocytes (white blood cells - WBCs), their specific surface morphology (globular prominences and depression in WBCs) as well as their local elastic properties (Young’s modulus) in healthy persons and in patients with type 2 diabetes mellitus (T2DM) by means of the atomic force microscopy (AFM). Morphological and morphometrical parameters of human leukocytes were evaluated by AFM in tapped mode