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Title: General features of the energetics of complex formation between ligand and nucleic acids
Authors: Kostjukov, V. V.
Rogova, O. V.
Evstigneev, M. P.
Keywords: biology
nucleic acids
biologically active compounds
free energy decomposition
energetic contributions
physical factors
aqueous solution
Issue Date: 2014
Citation: Kostjukov, V.V. General features of the energetics of complex formation between ligand and nucleic acids / V. V. Kostjukov, O. V. Rogova, M. P. Evstigneev // Biophysics. - 2014. - Vol.59, №4.-P. 546-551.
Abstract: The analysis of the energy contributions of various physical factors to the complex formation between biologically active compounds and nucleic acids in aqueous solution was performed. A comparison of the energy parameters was made for ligand-ligand, intercalator-DNA, MGB-DNA and ligand-RNA groups. It was shown that the energetics of these reactions is of compensatory nature. Physical factors exerting the most pronounced influence on the energy parameters were identified. Correlation of the energy contributions to MGB-DNA complex formation and its biological effect was found
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