Nanotechnological approach to evaluation of mechanical properties of cell surfaces during stimulation and blockade of adrenoceptors

Abstract

We used a new nanotechnological approach for evaluation of functional activity of adrenoceptors during treatment of cell surfaces with various drugs. Local elasticity maps by nanoindentation points were constructed, which show the targets for drugs on transporter cells under natural conditions. The applied approach allowed identifi cation of structural transformations in the membrane leading to changes in its elasticity, which can be used in cell physiology studies for controlling the processes of cell signaling