|Title:||Genetically modified animal models of hereditary diseases for testing of gene-directed therapy|
|Authors:||Polikarpova, A. V.|
Egorova, T. V.
Bardina, M. V.
animal models of human diseases
|Citation:||Polikarpova, A.V. Genetically modified animal models of hereditary diseases for testing of gene-directed therapy / A.V. Polikarpova, T.V. Egorova, M.V. Bardina // Research Results in Pharmacology. - 2022. - Vol.8, №2.-P. 11-26. - Doi: 10.3897/rrpharmacology.8.82618. - Refer.: p. 22-26.|
|Abstract:||Given the specific gene therapy approach, appropriate animal models can be generated using a variety of technologies ranging from transgenesis to precise genome editing. In this review, we discuss technologies used to generate small and large animal models of the most common muscular and neurological genetic disorders. We specifically focus on animal models that were used to test gene therapies based on adeno-associated vectors and antisense nucleotides|
|Appears in Collections:||Vol. 8, № 2|
|Polikarpova_Genetically.pdf||1.01 MB||Adobe PDF||View/Open|
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