|Title:||Pharmacological efficacy of an inhibitor of arginase-2 KUD975 with L-NAME-induced endothelial dysfunction|
|Authors:||Kudryavtsev, K. V.|
Korokin, M. V.
Gudyrev, O. S.
compounds of phenolic nature
|Citation:||Kudryavtsev, K.V. Pharmacological efficacy of an inhibitor of arginase-2 KUD975 with L-NAME-induced endothelial dysfunction / K. V. Kudryavtsev, M. V. Korokin, O. S. Gudyrev // Research result. Pharmacology and clinical pharmacology. - 2017. - Vol. 3, № 1.- P. 10-17. - Doi: 10.18413/2500-235X-2017-3-1-10-17. - Refer.: p. 17.|
|Abstract:||The study of endotelio- and cardioprotective activity of finished dosage forms - tablets, film-coated, containing 10 mg of phenolic nature KUD-975, was shown a statistically significant decrease in blood pressure and the coefficient of endothelial dysfunction on the background of simulation L-NAME-induced pathology. In the group of animals treated with KUD975 found a statistically significant increase in the concentrations of stable metabolites of nitric oxide, which in addition to the normalization of vasodilation says about endothelioprotektive action of the compounds studied|
|Appears in Collections:||Vol. 3, № 1|
|Kudryavtsev_Pharmacologocal_17.pdf||805.56 kB||Adobe PDF||View/Open|
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