http://dspace.bsu.edu.ru/handle/123456789/46598| Title: | Pharmacological efficacy of an inhibitor of arginase-2 KUD975 with L-NAME-induced endothelial dysfunction |
| Authors: | Kudryavtsev, K. V. Korokin, M. V. Gudyrev, O. S. |
| Keywords: | medicine pharmacology endothelial dysfunction arginase inhibitors compounds of phenolic nature |
| Issue Date: | 2017 |
| Citation: | Kudryavtsev, K.V. Pharmacological efficacy of an inhibitor of arginase-2 KUD975 with L-NAME-induced endothelial dysfunction / K. V. Kudryavtsev, M. V. Korokin, O. S. Gudyrev // Research result. Pharmacology and clinical pharmacology. - 2017. - Vol. 3, № 1.- P. 10-17. - Doi: 10.18413/2500-235X-2017-3-1-10-17. - Refer.: p. 17. |
| Abstract: | The study of endotelio- and cardioprotective activity of finished dosage forms - tablets, film-coated, containing 10 mg of phenolic nature KUD-975, was shown a statistically significant decrease in blood pressure and the coefficient of endothelial dysfunction on the background of simulation L-NAME-induced pathology. In the group of animals treated with KUD975 found a statistically significant increase in the concentrations of stable metabolites of nitric oxide, which in addition to the normalization of vasodilation says about endothelioprotektive action of the compounds studied |
| URI: | http://dspace.bsu.edu.ru/handle/123456789/46598 |
| Appears in Collections: | Vol. 3, № 1 |
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kudryavtsev_Pharmacologocal_17.pdf | 805.56 kB | Adobe PDF | View/Open |
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