http://dspace.bsu.edu.ru/handle/123456789/46596| Title: | The development of hypertensive neuroretinopathy model on wistar rats |
| Authors: | Peresypkina, A. A. Dolzhikov, A. A. Gubareva, V. O. Levkova, E. A. Shabelnikova, A. S. |
| Keywords: | medicine pharmacology hypertensive neuroretinopathy ophthalmoscopy laser Doppler flowmetry electroretinography experiments |
| Issue Date: | 2017 |
| Citation: | The development of hypertensive neuroretinopathy model on wistar rats / A. A. Peresypkina [et al.] // Research result. Pharmacology and clinical pharmacology. - 2017. - Vol. 3, № 1.- P. 18-31. - Doi: 10.18413/2500-235X-2017-3-1-18-31. - Refer.: p. 30-31. |
| Abstract: | A model of hypertensive neuroretinopathy was developed on Wistar line rats with administration of non-selective NO-synthase blocker N-nitro-L-arginine methyl ester (L-NAME) in a dose 12.5 mg/kg within 28 days on the background of single increased intraocular pressure (IOP) to 110 mmHg. As a result of the interim evaluation of pathology simulation mode the most optimal was a model of hypertensive neuroretinopathy with 5-minute increased IOP at day 26 of the experiment on the background of L-NAME for further study of neuroretinoprotective properties of pharmacological agents |
| URI: | http://dspace.bsu.edu.ru/handle/123456789/46596 |
| Appears in Collections: | Vol. 3, № 1 |
| File | Description | Size | Format | |
|---|---|---|---|---|
| Peresypkina_The_development_17.pdf | 995.19 kB | Adobe PDF | View/Open |
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