http://dspace.bsu.edu.ru/handle/123456789/46569| Title: | Test system for evaluation of the influence of the biological activity of substances on the signal system of NF-κB: focus on the derivatives of 3- hydroxypyridine |
| Authors: | Skachilova, S. Y. Ragulina, V. A. Kostina, D. A. Burda, Y. E. |
| Keywords: | medicine pharmacology Nuclear factor kappa B NF-κB 3-hydroxypyridine derivatives pharmacological correction |
| Issue Date: | 2017 |
| Citation: | Test system for evaluation of the influence of the biological activity of substances on the signal system of NF-κB: focus on the derivatives of 3- hydroxypyridine / S.Y. Skachilova [et al.] // Research result: pharmacology and clinical pharmacology. - 2017. - Vol. 3, № 2.- P. 50-56. - Doi: 10.18413/2313-8971-2017-3-2-50-56. |
| Abstract: | At the first stage of our study, 11 pharmacological agents-inhibitors of NF-κB in vitro were screened with an estimate of the activity of the p65 subunit in mononuclear cells stimulated by bacterial lipopolysaccharide. The most active substances were: mexidol, ethoxidol and the agent under the code XS-9. Further inhibitory activity against NF-κB pharmacological agents was studied on 4 models: L-NAME-induced endothelial dysfunction, staphylococcal sepsis, acute toxic liver damage and acute pancreatitis |
| URI: | http://dspace.bsu.edu.ru/handle/123456789/46569 |
| Appears in Collections: | Vol. 3, № 2 |
| File | Description | Size | Format | |
|---|---|---|---|---|
| Skachilova_Test_system_17.pdf | 1.01 MB | Adobe PDF | View/Open |
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