http://dspace.bsu.edu.ru/handle/123456789/46292| Title: | New personalized genetic mouse model of Lesch-Nyhan syndrome for pharmacology and gene therapy |
| Authors: | Kalmykov., V. A. Kusov, P. A. Yablonskaia, M. I. Korshunov, E. N. Korshunova, D. S. |
| Keywords: | medicine pharmacology transgenic mice Lesch-Nyhan syndrome personalized medicine orphane deases |
| Issue Date: | 2018 |
| Citation: | New personalized genetic mouse model of Lesch-Nyhan syndrome for pharmacology and gene therapy / V.A. Kalmykov [et al.] // Research Results in Pharmacology. - 2018. - Vol. 4, № 4.- P. 115-122. - Doi: 10.3897/rrpharmacology.4.32209. - Refer.: p. 121-122. |
| Abstract: | In the current study, we present the results of the generation of a genetically modified mouse strain carrying a deletion in the HPRT1 gene. These mice can be effectively used for the preclinical testing of new drugs aimed at the treatment of Lesch-Nyhan syndrome |
| URI: | http://dspace.bsu.edu.ru/handle/123456789/46292 |
| Appears in Collections: | Vol. 4, № 4 |
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kalmykov_New_personalized.pdf | 959.71 kB | Adobe PDF | View/Open |
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