|Title:||Endothelioprotective property of the combination of the thioctic acid and rosuvastatin shown in the endothelial dysfunction models|
|Authors:||Molchanova, O. V.|
Pokrovskaya, T. G.
Povetkin, S. V.
Reznikov, K. M.
|Citation:||Endothelioprotective property of the combination of the thioctic acid and rosuvastatin shown in the endothelial dysfunction models / O.V. Molchanova [et al.] // Research Result: Pharmacology and Clinical Pharmacology. - 2016. - Vol.2, №1(2).-P. 9-15. - Doi: 10.18413/2313-8971-2016-2-1-9-15. - Refer.: p. 14-15.|
|Abstract:||During the experiment, the modeling of endothelial dysfunction of male rats was performed by intraperitoneal administration of L-NAME at a dose of 25 mg/kg for 7 days, and the same of female rats was performed by bilateral ovarioectomy and further intraperitoneal administration of L-NAME at a dose of 25 mg/kg for 7. The deficiency of nitric oxide as a result of the NO-synthase blockade was accompanied by the impairment of the endotheliumdependent and independent vasodilatation estimated in the pharmacological tests, which was expressed in the increasing coefficient of endothelial dysfunction|
|Appears in Collections:||Research Result. Pharmacology and Clinical Pharmacology|
|Pokrovskaya_Endothelioprotective.pdf||1.09 MB||Adobe PDF||View/Open|
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