|Title:||Test system for evaluation of the influence of the biological activity of substances on the signal system of NF-κB: focus on the derivatives of 3- hydroxypyridine|
|Authors:||Skachilova, S. Y.|
Ragulina, V. A.
Kostina, D. A.
Burda, Y. E.
Nuclear factor kappa B
|Citation:||Test system for evaluation of the influence of the biological activity of substances on the signal system of NF-κB: focus on the derivatives of 3- hydroxypyridine / S.Y. Skachilova [и др.] // Research result: pharmacology and clinical pharmacology. - 2017. - Т.3, №2.-С. 50-56. - DOI: 10.18413/2313-8971-2017-3-2-50-56.|
|Abstract:||At the first stage of our study, 11 pharmacological agents-inhibitors of NF-κB in vitro were screened with an estimate of the activity of the p65 subunit in mononuclear cells stimulated by bacterial lipopolysaccharide. The most active substances were: mexidol, ethoxidol and the agent under the code XS-9. Further inhibitory activity against NF-κB pharmacological agents was studied on 4 models: L-NAME-induced endothelial dysfunction, staphylococcal sepsis, acute toxic liver damage and acute pancreatitis|
|Appears in Collections:||Research Result. Pharmacology and Clinical Pharmacology|
|Skachilova_Test_system_17.pdf||1.01 MB||Adobe PDF||View/Open|
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