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Please use this identifier to cite or link to this item: http://dspace.bsu.edu.ru/handle/123456789/22997
Title: Test system for evaluation of the influence of the biological activity of substances on the signal system of NF-κB: focus on the derivatives of 3- hydroxypyridine
Authors: Skachilova, S. Y.
Ragulina, V. A.
Kostina, D. A.
Burda, Y. E.
Keywords: medicine
pharmacology
Nuclear factor kappa B
NF-κB
3-hydroxypyridine derivatives
pharmacological correction
Issue Date: 2017
Citation: Test system for evaluation of the influence of the biological activity of substances on the signal system of NF-κB: focus on the derivatives of 3- hydroxypyridine / S.Y. Skachilova [и др.] // Research result: pharmacology and clinical pharmacology. - 2017. - Т.3, №2.-С. 50-56. - DOI: 10.18413/2313-8971-2017-3-2-50-56.
Abstract: At the first stage of our study, 11 pharmacological agents-inhibitors of NF-κB in vitro were screened with an estimate of the activity of the p65 subunit in mononuclear cells stimulated by bacterial lipopolysaccharide. The most active substances were: mexidol, ethoxidol and the agent under the code XS-9. Further inhibitory activity against NF-κB pharmacological agents was studied on 4 models: L-NAME-induced endothelial dysfunction, staphylococcal sepsis, acute toxic liver damage and acute pancreatitis
URI: http://dspace.bsu.edu.ru/handle/123456789/22997
Appears in Collections:Research Result. Pharmacology and Clinical Pharmacology

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