|Title:||Pleyotropic antiaggregant effects of an innovative antiarrhythmic of class III SS-68, an indole derivative|
|Authors:||Bogus, S. K.|
Dukhanin, A. S.
Kucheryavenko, A. F.
Vinakov, D. V.
Suzdalev, K. F.
molecular targets of anti-platelet effect
|Citation:||Pleyotropic antiaggregant effects of an innovative antiarrhythmic of class III SS-68, an indole derivative / S.K. Bogus [et al.] // Research result: pharmacology and clinical pharmacology. - 2017. - Vol.3, №2.-P. 3-13. - DOI: 10.18413/2313-8971-2017-3-2-3-13.|
|Abstract:||A new indole derivative with the lab code-number SS-68 demonstrates a significant antiarrhythmic (anti-fibrillation) activity associated with the predominant influence on potassium and calcium conductivity of cardiomyocytes plasmalemmas. The preliminary data give evidence of SS-68 possessing an antiaggregant activity. The influence of SS-68 on the platelet formation stage of hemostasis was determined by assessment of the anti-platelet effect (measuring platelet aggregation with Born/ O’Brien method), the dynamics of intracellular concentration of calcium ions in platelets was studied with FURA-2/АМ fluorescent probe|
|Appears in Collections:||Research Result. Pharmacology and Clinical Pharmacology|
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