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Please use this identifier to cite or link to this item: http://dspace.bsu.edu.ru/handle/123456789/22990
Title: Pleyotropic antiaggregant effects of an innovative antiarrhythmic of class III SS-68, an indole derivative
Authors: Bogus, S. K.
Dukhanin, A. S.
Kucheryavenko, A. F.
Vinakov, D. V.
Suzdalev, K. F.
Keywords: medicine
pharmacology
SS-68 compound
platelet aggregation
disaggregation
intracellular calcium
molecular targets of anti-platelet effect
Issue Date: 2017
Citation: Pleyotropic antiaggregant effects of an innovative antiarrhythmic of class III SS-68, an indole derivative / S.K. Bogus [и др.] // Research result: pharmacology and clinical pharmacology. - 2017. - Т.3, №2.-С. 3-13. - DOI: 10.18413/2313-8971-2017-3-2-3-13.
Abstract: A new indole derivative with the lab code-number SS-68 demonstrates a significant antiarrhythmic (anti-fibrillation) activity associated with the predominant influence on potassium and calcium conductivity of cardiomyocytes plasmalemmas. The preliminary data give evidence of SS-68 possessing an antiaggregant activity. The influence of SS-68 on the platelet formation stage of hemostasis was determined by assessment of the anti-platelet effect (measuring platelet aggregation with Born/ O’Brien method), the dynamics of intracellular concentration of calcium ions in platelets was studied with FURA-2/АМ fluorescent probe
URI: http://dspace.bsu.edu.ru/handle/123456789/22990
Appears in Collections:Research Result. Pharmacology and Clinical Pharmacology

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