Skip navigation
BelSU DSpace logo

Please use this identifier to cite or link to this item: http://dspace.bsu.edu.ru/handle/123456789/21631
Title: Ligand of peripheral imidazoline receptors based on amides of heterocyclic acids C7070: effect on ishemized tissues
Authors: Dovgan, A. P.
Keywords: medicine
pharmacology
Biology
zoology
physiology of animals
С7070
metformin
moxonidine
ischemia
reperfusion
liver
skin flap
isolated heart
according to Langendorf
Issue Date: 2017
Citation: Dovgan, A.P. Ligand of peripheral imidazoline receptors based on amides of heterocyclic acids C7070: effect on ishemized tissues / A.P. Dovgan // Research result. Pharmacology and clinical pharmacology. - 2017. - Vol.3, №4.- P. 78-88. - DOI: 10.18413/2313-8971-2017-3-4-78-88. - Refer.: p. 85-88.
Series/Report no.: Pharmacology and clinical pharmacology;
Abstract: In this regard, the study of pleiotropic hepatoprotective properties of the agonist of peripheral imidazoline receptors C7070 seems interesting from an applied point of view. Models of a skin flap on a feeding leg, ischemia-reperfusion of the liver and rat heart isolated from Langendorff (ischemia-reperfusion and doxorubicin cardiomyopathy) were used. The I2 agonist C7070 at a dose of 10 mg/kg 4.5-fold prevents the increase in ALT and AST (332.56 ± 22.05/825.49 ± 22.46 ALT/AST 526.90 ± 17.97/1045.16 ± 80.02 units/l in control) and 2.5 times reduces the areas of ischmeic damage and necrosis (0.058 ± 0.029/0.046 ± 0.013 mm2) in the modeling of 15-minute ischemia liver. Moxonidine and metformin had a hepatoprotective effect: 44.99 and 36.88 for moxonidine (ALT and AST) and 34.20 / 21.02 for metformin (ALT / AST). The coefficients of histological hepatoprotective activity: 72.33 and 38.96 (moxonidine and metformin)
URI: http://dspace.bsu.edu.ru/handle/123456789/21631
Appears in Collections:Research Result. Pharmacology and Clinical Pharmacology

Files in This Item:
File Description SizeFormat 
Dovgan_Ligand_17.pdf2.4 MBAdobe PDFView/Open
Show full item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.