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Please use this identifier to cite or link to this item: http://dspace.bsu.edu.ru/handle/123456789/21465
Title: Possible ways of pharmacological correction of ischemic damage to the liver with the agonist of peripheral imidazoline receptors C7070
Authors: Dovgan, A. P.
Urojevskaya, J. S.
Khavansky, A. V.
Keywords: medicine
pharmacology
clinical hepatology
Liver ischemia
liver reperfusion
diabetes mellitus
C7070
moxonidine
metformin
imidazoline receptor agonists
Issue Date: 2017
Citation: Dovgan, A.P. Possible ways of pharmacological correction of ischemic damage to the liver with the agonist of peripheral imidazoline receptors C7070 / A.P. Dovgan, J.S. Urojevskaya, A.V. Khavansky // Research result. Pharmacology and clinical pharmacology. - 2017. - Vol.3, №3.-P. 3-8. - DOI: 10.18413/2313-8971-2017-3-3-3-8.
Abstract: We glad to introduce several variants of pharmacological correction of ischemic hepatic injury by imidazoline I2 receptor agonist С7070. Materials and methods: The experiment was carried out on 70 rats of both sexes, divided into 7 groups (n = 10). The indicated agonists of peripheral imidazoline I2receptors (C7070) significantly reducesischemically-reperfusion injury of the liver, in comparison with the preparations of moxonidine and metformine. Indirect sign of imidazoline activating mechanism of C7070 is decreasing of the hepatoprotective effect of C7070 by the preliminary administration of imidazoline receptor blocker BU-224
URI: http://dspace.bsu.edu.ru/handle/123456789/21465
Appears in Collections:Research Result. Pharmacology and Clinical Pharmacology

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