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Title: Lipid distress-syndrome and prospects of its correction by statines
Authors: Denisiuk, T. A.
Lazareva, G. A.
Provotorov, V. Y.
Keywords: medicine
endothelial dysfunction
endotoxin-induced pathology
PI3K/Akt pathways
Issue Date: 2017
Citation: Denisiuk, T.A. Lipid distress-syndrome and prospects of its correction by statines / T.A. Denisiuk, G.A. Lazareva, V.Y. Provotorov // Research result. Pharmacology and clinical pharmacology. - 2017. - Vol.3, №3.-P. 135-156. - DOI: 10.18413/2313-8971-2017-3-3-135-156.
Abstract: Endothelial dysfunction in peritonitis: The formed concept of lipid distress syndrome (LDS) allows us to develop a working hypothesis on the key role of endothelial dysfunction in the aggressive development of atherosclerosis. The role of vascular endothelium in atherosclerosis: The process of NO production from L-arginine through eNOS involving tetrahydrobiopterin (BH4) is discussed. With the degradation of BH4 along the free radical path, an "eNOS uncouplation" (uncoupled eNOS). The clinical role of statins: Statins manifests itself by inhibiting the enzyme 3-hydroxy- 3-methylglutaryl-coenzyme A (HMG-CoA reductase). Many large, randomized clinical trials have shown that lipid-lowering strategies that include statins have an anti-atherogenic potential
Appears in Collections:Research Result. Pharmacology and Clinical Pharmacology

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