|Title:||The development of hypertensive neuroretinopathy model on wistar rats|
|Authors:||Peresypkina, A. A.|
Dolzhikov, A. A.
Gubareva, V. O.
Levkova, E. A.
Shabelnikova, A. S.
laser Doppler flowmetry
|Citation:||The development of hypertensive neuroretinopathy model on wistar rats / A. A. Peresypkina [et al.] // Research result. Pharmacology and clinical pharmacology. - 2017. - Vol.3, №1.-P. 18-31. - DOI : 10.18413/2500-235X-2017-3-1-18-31. - Refer.: p. 30-31.|
|Abstract:||A model of hypertensive neuroretinopathy was developed on Wistar line rats with administration of non-selective NO-synthase blocker N-nitro-L-arginine methyl ester (L-NAME) in a dose 12.5 mg/kg within 28 days on the background of single increased intraocular pressure (IOP) to 110 mmHg. As a result of the interim evaluation of pathology simulation mode the most optimal was a model of hypertensive neuroretinopathy with 5-minute increased IOP at day 26 of the experiment on the background of L-NAME for further study of neuroretinoprotective properties of pharmacological agents|
|Appears in Collections:||Research Result. Pharmacology and Clinical Pharmacology|
|Peresypkina_The_development_17.pdf||991.54 kB||Adobe PDF||View/Open|
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