|Title:||Study of dose-dependent effect of 2-ethyl-6-methyl-3 hydroxypyridine succinate on the contractile function of isolated rat heat|
|Authors:||Kesarev, O. G.|
Danilenko, L. M.
Pokrovskii, M. V.
Timokhina, A. S.
Khavanskii, A. V.
2-ethyl-6-methyl-3 hydroxypyridine succinate
|Citation:||Study of dose-dependent effect of 2-ethyl-6-methyl-3 hydroxypyridine succinate on the contractile function of isolated rat heat / O. G. Kesarev [et al.] // Research result. Pharmacology and clinical pharmacology. - 2017. - Vol.3, №1.-P. 3-9. - DOI : 10.18413/2500-235X-2017-3-1-3-9. - Refer.: p. 8-9.|
|Abstract:||In experiments on the isolated rat heart there were studied the effects of different doses (21.43 mg/kg/day and 85 . 72 mg/kg/day) 2-ethyl-6-methyl-3 hydroxypy ridine succinate ("EkoPharmInvest", Russia), on the contractile function of isolated hearts subjected to prior doxorubicin model (20 mg/kg, intraperitoneal) of pathology. The dynamic of the power mechanisms of ion transport was evaluated by imposing high h eart rate (480 BPM) and increase concentration of Са2+ to 5 mmol in perfusate|
|Appears in Collections:||Research Result. Pharmacology and Clinical Pharmacology|
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