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Please use this identifier to cite or link to this item: http://dspace.bsu.edu.ru/handle/123456789/19829
Title: Study of dose-dependent effect of 2-ethyl-6-methyl-3 hydroxypyridine succinate on the contractile function of isolated rat heat
Authors: Kesarev, O. G.
Danilenko, L. M.
Pokrovskii, M. V.
Timokhina, A. S.
Khavanskii, A. V.
Keywords: medicine
pharmacology
2-ethyl-6-methyl-3 hydroxypyridine succinate
doxorubicin
reperfusion
isolated heart
antioxidant
Issue Date: 2017
Citation: Study of dose-dependent effect of 2-ethyl-6-methyl-3 hydroxypyridine succinate on the contractile function of  isolated rat heat / O. G. Kesarev [et al.] // Research result. Pharmacology and clinical pharmacology. - 2017. - Vol.3, №1.-P. 3-9. - DOI : 10.18413/2500-235X-2017-3-1-3-9. - Refer.: p. 8-9.
Abstract: In experiments on the isolated rat heart there were studied the effects of different doses (21.43 mg/kg/day and 85 . 72 mg/kg/day) 2-ethyl-6-methyl-3 hydroxypy ridine succinate ("EkoPharmInvest", Russia), on the contractile function of isolated hearts subjected to prior doxorubicin model (20 mg/kg, intraperitoneal) of pathology. The dynamic of the power mechanisms of ion transport was evaluated by imposing high h eart rate (480 BPM) and increase concentration of Са2+ to 5 mmol in perfusate
URI: http://dspace.bsu.edu.ru/handle/123456789/19829
Appears in Collections:Research Result. Pharmacology and Clinical Pharmacology

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