Skip navigation
BelSU DSpace logo

Please use this identifier to cite or link to this item: http://dspace.bsu.edu.ru/handle/123456789/19815
Title: Anticholinergic activity and pharmacokinetic parameters of agent SS-68 with properties of class III antiarrhythmic drugs
Authors: Bogus, S. K.
Kulikov, A. L.
Vinakov, D. V.
Suzdalev, K. P.
Galenko-Yaroshevskii, P. A.
Keywords: medicine
pharmacology
vagus nerve
neurogenic atrial fibrillation
indole derivate SS-68
antiarrhythmic action
pharmacokinetics
Issue Date: 2016
Citation: Anticholinergic activity and pharmacokinetic parameters of agent SS-68 with properties of class III antiarrhythmic drugs / S. K. Bogus [и др.] // Research result: pharmacology and clinical pharmacology. - 2016. - Т.2, №3.- С. 3-10. - DOI: 10.18413/2500-235X-2016-2-3-3-10. - Refer.: p. 9-10.
Abstract: It was shown that the indole derivate SS-68 (50 and 250 μg/kg intravenous) in acute experiments on cats with neurogenic atrial fibrillation (AF) has a dose-dependent antiarrhythmic action which is associated with the neurotropic influence of this substance, since the suppression of the AF coincides with its anticholinergic effect observed for more than 2 hours, but cardiotropic action at this time was not observed. High antiarrhythmic activity of SS-68 to neurogenic AF may be due to the IKAch inhibition and blockade of M2-cholinergic receptors
URI: http://dspace.bsu.edu.ru/handle/123456789/19815
Appears in Collections:Статьи из периодических изданий и сборников (на иностранных языках) = Articles from periodicals and collections (in foreign languages)

Files in This Item:
File Description SizeFormat 
Bogus_Anticholinergic_16.pdf1.07 MBAdobe PDFView/Open
Show full item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.