|Title:||Anticholinergic activity and pharmacokinetic parameters of agent SS-68 with properties of class III antiarrhythmic drugs|
|Authors:||Bogus, S. K.|
Kulikov, A. L.
Vinakov, D. V.
Suzdalev, K. P.
Galenko-Yaroshevskii, P. A.
neurogenic atrial fibrillation
indole derivate SS-68
|Citation:||Anticholinergic activity and pharmacokinetic parameters of agent SS-68 with properties of class III antiarrhythmic drugs / S. K. Bogus [et al.] // Research result: pharmacology and clinical pharmacology. - 2016. - Vol.2, №3.- P. 3-10. - DOI: 10.18413/2500-235X-2016-2-3-3-10. - Refer.: p. 9-10.|
|Abstract:||It was shown that the indole derivate SS-68 (50 and 250 μg/kg intravenous) in acute experiments on cats with neurogenic atrial fibrillation (AF) has a dose-dependent antiarrhythmic action which is associated with the neurotropic influence of this substance, since the suppression of the AF coincides with its anticholinergic effect observed for more than 2 hours, but cardiotropic action at this time was not observed. High antiarrhythmic activity of SS-68 to neurogenic AF may be due to the IKAch inhibition and blockade of M2-cholinergic receptors|
|Appears in Collections:||Research Result. Pharmacology and Clinical Pharmacology|
|Bogus_Anticholinergic_16.pdf||1.07 MB||Adobe PDF||View/Open|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.