|Title:||Assessment of the DNA damage level in peripheral blood leukocytes of mice treated orally with Rapitalam in acute and therapeutic doses|
|Authors:||Kravchenko, D. V.|
Avdeeva, N. V.
Korokin, M. V.
physiology of animals
|Citation:||Kravchenko, D.V. Assessment of the DNA damage level in peripheral blood leukocytes of mice treated orally with Rapitalam in acute and therapeutic doses / D. V. Kravchenko, N. V. Avdeeva, M. V. Korokin // Research result: pharmacology and clinical pharmacology. - 2016. - Vol.2, №4.- P. 9-11. - DOI: 10.18413/2500-235 X-2016-2-4-9-11. - Refer.: p. 11.|
|Abstract:||Centre there was performed experimental research, which carried out the identification and quantitative assessment of alkali-labile sites and DNA strand breaks in leukocytes of peripheral blood of male mice treated with Rapitalam. The method is based on the assessment of the integrity of DNA in leukocytes of the whole blood of animals. Rapitalam was administered to animals orally according to 2 schemes: a single acute dose (413 mg/kg, which corresponds to 1/5 LD50 dose) and once daily in a therapeutic dose (3 mg/kg) for 4 days|
|Appears in Collections:||Research Result. Pharmacology and Clinical Pharmacology|
|Kravchenko_Assessment_16.pdf||574.24 kB||Adobe PDF||View/Open|
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