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Please use this identifier to cite or link to this item: http://dspace.bsu.edu.ru/handle/123456789/17475
Title: Method of correction of endothelial dysfunction with combination of ademetionine and taurine
Authors: Khadieva, T. A.
Dovgan, A. P.
Pokroskaya, T. G.
Keywords: medicine
pharmacology
L-NAME
endothelial dysfunction
taurine
ademetionine
nitric oxide
oxidative stress
Issue Date: 2016
Citation: Khadieva, T. A. Method of correction of endothelial dysfunction with combination of ademetionine and taurine / T. A. Khadieva, A. P. Dovgan, T. G. Pokroskaya // Research Result: Pharmacology and Clinical Pharmacology. - 2016. - Vol.2, №2(3).-P. 36-40. - DOI : 10.18413/2313-8971-2016-2-2-36-40. - Refer.: p. 39-40.
Abstract: In the experiment, was made a simulation of endothelial dysfunction in male rats of Wistar-line byintraperitoneal administration of L-NAME at a dose of 25 mg/kg/day for 7 days. Deficiency of nitric oxide in result of the blockade of NO-synthase was accompanied by violation of endothelium-dependent and endothelium-undependentvasodilation assessed in pharmacological trials, which was reflected in the increase of the coefficient endotelialny dysfunction.In this case, for correction of endothelial dysfunction intraperitoneallyademetionine in the dose of 150 mg/kg and after an hour taurine at a dose of 260 mg/kg was injected the animal once a day for 7 days
URI: http://dspace.bsu.edu.ru/handle/123456789/17475
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