DSpace Collection: http://dspace.bsuedu.ru/handle/123456789/46282 2026-04-07T18:49:16Z Antiamnestic effect of new nicotinic acid derivatives http://dspace.bsuedu.ru/handle/123456789/46655 Title: Antiamnestic effect of new nicotinic acid derivatives Authors: Yasnetsov, V. V.; Kaurova, D. E.; Skachilova, S. Ya.; Bersenev, E. Yu. Abstract: The search for new drugs for the prevention and treatment of vascular cognitive disorders continues to be a relevant task of pharmacology. In this regard, the aim of this work is to study the antiamnestic effect of five new nicotinic acid derivatives in comparison with the well-known drug mexidol (ethylmethylhydroxypyridine succinate) in animals 2021-01-01T00:00:00Z Effect of adjuvant drugs on the analgesic activity of opioid morphine analgesics and compound RU-1205 http://dspace.bsuedu.ru/handle/123456789/46654 Title: Effect of adjuvant drugs on the analgesic activity of opioid morphine analgesics and compound RU-1205 Authors: Spasov, A. A.; Grechko, O. I.; Eliseeva, N. V.; Lifanova, Yu. V.; Aleksandrenkova, A. N. Abstract: Adjuvant medications can be used to increase the analgesic effect of opioid analgesics, reduce the manifestation of side effects, and also for premedication. This paper provides information on the effect of clonidine, haloperidol, metocloparmide, diazepam, midazolam on opioid analgesics: - morphine and the selective kappa-opioid agonist compound RU-1205 2021-01-01T00:00:00Z Neuropharmacological characteristics of antidepressant action of a new 3-substituted thietane-1,1-dioxide derivative http://dspace.bsuedu.ru/handle/123456789/46653 Title: Neuropharmacological characteristics of antidepressant action of a new 3-substituted thietane-1,1-dioxide derivative Authors: Nikitina, I. L.; Gaisina, G. G. Abstract: Due to severe burden of depressive disorders and a low rate of remission in patients receiving antidepressant therapy, there is an urgent need for developing novel agents with antidepressant action and a fundamentally new mechanism of action. 3-ethoxythietane-1,1-dioxide (N-199/1) is a new molecule that showed significant antidepressant properties when administered intraperitoneally once or repeatedly. The aim of the present study was to investigate the mechanism of action of N-199/1, using reserpine test 2021-01-01T00:00:00Z Neuroprotective and cerebrovascular effects of endogenous N-Arachidonoyl-GABA and its putative Cox-2 metabolite - GABA conjugate with Prostaglandin E2 http://dspace.bsuedu.ru/handle/123456789/46652 Title: Neuroprotective and cerebrovascular effects of endogenous N-Arachidonoyl-GABA and its putative Cox-2 metabolite - GABA conjugate with Prostaglandin E2 Authors: Mirzoyan, N. R.; Khostikyan, N. G.; Meliksetyan, V. S.; Hakobyan, A. A.; Ganshina, T. S. Abstract: The aim of the study was to compare the neuroprotective and cerebrovascular effects of bioactive, endogenous lipid-N-arachidonoyl-GABA (AA-GABA) and GABA conjugate with prostaglandin E2 (PGE2-GABA) by evaluation of a morphological state of rat brain tissue and lipofuscin levels under the condition of permanent focal brain ischemia, as well as cerebral circulation under the condition of global transient ischemia 2021-01-01T00:00:00Z