DSpace Collection:http://dspace.bsu.edu.ru/handle/123456789/462622024-03-29T09:25:26Z2024-03-29T09:25:26ZLipid distress-syndrome and prospects of its correction by statinesDenisiuk, T. A.Lazareva, G. A.Provotorov, V. Y.http://dspace.bsu.edu.ru/handle/123456789/465812022-05-05T00:08:29Z2017-01-01T00:00:00ZTitle: Lipid distress-syndrome and prospects of its correction by statines
Authors: Denisiuk, T. A.; Lazareva, G. A.; Provotorov, V. Y.
Abstract: Endothelial dysfunction in peritonitis: The formed concept of lipid distress syndrome (LDS) allows us to develop a working hypothesis on the key role of endothelial dysfunction in the aggressive development of atherosclerosis. The role of vascular endothelium in atherosclerosis: The process of NO production from L-arginine through eNOS involving tetrahydrobiopterin (BH4) is discussed. With the degradation of BH4 along the free radical path, an "eNOS uncouplation" (uncoupled eNOS). The clinical role of statins: Statins manifests itself by inhibiting the enzyme 3-hydroxy- 3-methylglutaryl-coenzyme A (HMG-CoA reductase). Many large, randomized clinical trials have shown that lipid-lowering strategies that include statins have an anti-atherogenic potential2017-01-01T00:00:00ZPossible ways of pharmacological correction of ischemic damage to the liver with the agonist of peripheral imidazoline receptors C7070Dovgan, A. P.Urojevskaya, J. S.Khavansky, A. V.http://dspace.bsu.edu.ru/handle/123456789/465802022-05-05T00:32:26Z2017-01-01T00:00:00ZTitle: Possible ways of pharmacological correction of ischemic damage to the liver with the agonist of peripheral imidazoline receptors C7070
Authors: Dovgan, A. P.; Urojevskaya, J. S.; Khavansky, A. V.
Abstract: We glad to introduce several variants of pharmacological correction of ischemic hepatic injury by imidazoline I2 receptor agonist ะก7070. Materials and methods: The experiment was carried out on 70 rats of both sexes, divided into 7 groups (n = 10). The indicated agonists of peripheral imidazoline I2receptors (C7070) significantly reducesischemically-reperfusion injury of the liver, in comparison with the preparations of moxonidine and metformine. Indirect sign of imidazoline activating mechanism of C7070 is decreasing of the hepatoprotective effect of C7070 by the preliminary administration of imidazoline receptor blocker BU-2242017-01-01T00:00:00ZInterleukin-6 is a potential target for a correction of endothelial dysfunction associated with low-grade systemic inflammationKostina, D. A.Pokrovskaya, T. G.Beskhmelnitsyna, E. A.http://dspace.bsu.edu.ru/handle/123456789/465782022-05-05T00:28:43Z2017-01-01T00:00:00ZTitle: Interleukin-6 is a potential target for a correction of endothelial dysfunction associated with low-grade systemic inflammation
Authors: Kostina, D. A.; Pokrovskaya, T. G.; Beskhmelnitsyna, E. A.
Abstract: One of pathogenetic links of development of endothelial dysfunction, as an early marker of cardiovascular disease and comorbidity, is a low-grade systemic inflammation. In this regard, correction of cytokines imbalance is one of the possible ways of prevention and treatment of major chronic noninfectious diseases. To study the endothelium protective effects of anti-IL-6 receptor monoclonal antibodies tocilizumab in experimental preclinical studies in a model of endothelial dysfunction associated with the low-grade systemic inflammation2017-01-01T00:00:00ZResearch of wound healing effect of phytomineralsorbent on the basis of montmorilloniteKrut, U. A.Shaposhnikov, A. A.Korokin, M. V.http://dspace.bsu.edu.ru/handle/123456789/465752022-05-05T00:18:16Z2017-01-01T00:00:00ZTitle: Research of wound healing effect of phytomineralsorbent on the basis of montmorillonite
Authors: Krut, U. A.; Shaposhnikov, A. A.; Korokin, M. V.
Abstract: The results of preclinical investigation of the wound healing effect of phytomineralsorbent (PMS) based on montmorillonite are presented. Objectives: Study of the possibilities of pharmacological correction of purulent wound process with the help of various medicinal forms of phytomineral sorbent based on montmorillonite2017-01-01T00:00:00Z